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Most of the drugs used in the treatment of aggressive syndromes have originally been developed for other clinical applications. Despite ificant differences in the pathogenesis of various aggressive disorders, the frequently used "antiaggression" drugs are the major tranquilizers neuroleptics.
If the aggresstion is associated with psychosis, chlorpromazine or haloperidol are the drugs of choice. Aggressive disorders within the acute and chronic brain syndromes are best treated with pericyazine, thioridazine, and thiothixene. In aggressive symptoms of mentally retarded patients, particularly with epileptic syndromes, a new benzazepine SCH12, was found to be very effective. Aggression associated with alcoholism or narcotic addiction showed best response to chlorpormazine and haloperidol. As a general rule, in aggressive patients with clinically known epilepsy, or with abnormal electroencephalographic findings, the major tranquilizers with potent sedative properties should be given with great caution.
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Psychopharmacology Berl. Publication types Comparative Study Actions. Review Actions.
MeSH terms Adolescent Actions. Chronic Disease Actions. Electroencephalography Actions. Female Actions. Humans Actions. Phenothiazines Actions. Substances Antidepressive Agents Actions. Antipsychotic Agents Actions. Benzazepines Actions.
Butyrophenones Actions. Psychotropic Drugs Actions. Thioxanthenes Actions. Tranquilizing Agents Actions. Reserpine Actions. Molindone Actions. Copy Download.What are major tranquilizers
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Major tranquillizers can be distinguished from minor tranquillizers on the basis of effects on marble burying and swim-induced grooming in mice